Pre-seed & seed VC, US

SOSV

Venture capital firm · Princeton · Founded 1995

Quick read

SOSV is a pre-seed and multi-stage deep tech VC, founded in 1995 and headquartered in Princeton, NJ. It's the world's most active deep tech pre-seed firm, deploying capital through accelerator programs HAX (hardware), IndieBio (life sciences), and the recently independent Orbit Startups. As of 2026, SOSV manages $1.5B in AUM across a portfolio of 800 active companies valued at $18.2B.

Key facts

Founded
1995
Founders
Sean O'Sullivan
Employees
68
Sectors
hardware, biotech, climate, ai, healthcare
Website
sosv.com

Investment thesis

SOSV backs deep tech founders at pre-seed, writing first checks into life sciences, hardware, and climate companies through its accelerator programs (HAX for hardware, IndieBio for life sciences). The firm then follows on through seed and later rounds, aiming to build companies with measurable impact on human and planetary health.

Recent activity

  • Jul 2026press
    SOSV announced the Deep Tech Summit coming November 4–6, covering climate tech, human health, and AI for the physical world. sosv.com
  • Jul 2026investment
    SOSV hosted the 2026 VC-Founder Therapeutics Matchup (July 13–17), connecting 250+ startups with 250+ investors in 1:1 online meetings. SOSV has now closed 10 investments sourced directly from past matchups. sosv.com
  • May 2026press
    SOSV ran the 2026 VC-Founder Physical AI Matchup (May 11–15), a virtual event pairing 250+ startups with 250+ investors. The 2025 matchup series generated over 6,500 one-on-one meetings across health tech and related categories. sosv.com
  • Apr 2026fundraise
    SOSV confirmed $1.5B AUM anchored by the $306M SOSV V fund. At the start of 2026, its 800 active portfolio companies had raised $7.3B and were valued at $18.2B. sosv.com
  • Apr 2026press
    SOSV Innovation Day held April 27 in New York, hosted by partners from HAX and SOSV NY. Students and postdocs pitched hard tech and deep-bio ideas; the day included workshops on building hard tech startups and raising early-stage capital. hax.co
  • Apr 2026investment
    SOSV announced plans to invest in more than 25 plasma-related startups over the next five years, targeting next-generation semiconductor manufacturing and advanced materials. zoominfo.com
  • Mar 2026press
    IndieBio New York held an Investor Showcase on March 11, 2026, presenting its latest pre-seed cohort to the investment community. sosv.com
  • May 2026investment
    SOSV announced it's building a next-generation plasma-powered company program in Princeton, NJ, and is investing in more than 25 plasma-related startups over the next five years. sosv.com
  • May 2026press
    Portfolio company Prolific Machines reported 21 g/L productivity over 15 days in an intensified fed-batch CHO cell line run, a milestone for its photomolecular platform that uses light and optogenetics to manipulate gene expression. Covered by FiercePharma. sosv.com
  • Apr 2026press
    SOSV hosted a fireside chat with Sir Steven Cowley, Director of the U.S. Department of Energy's Princeton Plasma Physics Laboratory, on April 21, 2026. sosv.com
  • Apr 2026investment
    Portfolio company Fermeate raised $2M to advance precision fermentation economics using optogenetics, covered by AgFunder News. sosv.com
  • Mar 2026press
    SOSV hosted an exclusive investor showcase featuring pre-seed, seed, and Series A companies from IndieBio NY's portfolio on March 11, 2026. sosv.com

Notable investments

Key people

Named individuals at the firm. We don't expose direct email or phone — use their LinkedIn for outreach.

  • Sean O'Sullivan · Founder & Managing Director
    LinkedIn
  • Po Bronson · General Partner (SF & NY)
    LinkedIn
  • Parikshit Sharma · Partner, IndieBio
    LinkedIn

Sources

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Frequently asked

What is SOSV?+

SOSV is a pre-seed and multi-stage deep tech VC, founded in 1995 and headquartered in Princeton, NJ. It's the world's most active deep tech pre-seed firm, deploying capital through accelerator programs HAX (hardware), IndieBio (life sciences), and the recently independent Orbit Startups.

Where is SOSV headquartered?+

SOSV is headquartered in Princeton, United States.

When was SOSV founded?+

SOSV was founded in 1995 by Sean O'Sullivan.

What sectors does SOSV invest in?+

SOSV focuses on hardware, biotech, climate, ai, healthcare. They primarily invest in these sectors.

How do I prepare for a meeting with SOSV?+

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Generated by briefthecall.com from public web sources. Last updated July 23, 2026. Each claim is linked to its source above.

Automatically generated by AI from public sources. May be inaccurate or out of date. Remove or correct this profile →